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L-Carnitine | N-Acetyl-Cysteine | Selenium | Lipoic Acid

L-Carnitine

Diabetic neuropathy.

Bansal V, Kalita J, Misra UK.

Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareilly Road, Lucknow 226014, India.


Peripheric and automatic neuropathy in children with type 1 diabetes mellitus: the effect of L-carnitine treatment on the peripheral and autonomic nervous system.

Uzun N, Sarikaya S, Uluduz D, Aydin A.

Istanbul University Cerrahpasa Medical Faculty Neurology Department, Turkey.


Acetyl-L-carnitine improves pain, nerve regeneration, and vibratory perception in patients with chronic diabetic neuropathy: an analysis of two randomized placebo-controlled trials.

Sima AA, Calvani M, Mehra M, Amato A; Acetyl-L-Carnitine Study Group.

Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA. asima@med.wayne.edu


Effect of acetyl-L-carnitine on VIP-ergic neurons in the jejunum submucous plexus of diabetic rats.

Defani MA, Zanoni JN, Natali MR, Bazotte RB, de Miranda-Neto MH.

Departament of Sciences, State University of Maringa, Maringa, PR, Brazil. mad@visaonet.com.br


Acetyl-L-carnitine (levacecarnine) in the treatment of diabetic neuropathy. A long-term, randomised, double-blind, placebo-controlled study.

De Grandis D, Minardi C.

Department of Neuroscience, Ospedale Civile, Rovigo, Italy. ddegrandis@iol.it


Dissection of metabolic, vascular, and nerve conduction interrelationships in experimental diabetic neuropathy by cyclooxygenase inhibition and acetyl-L-carnitine administration.

Pop-Busui R, Marinescu V, Van Huysen C, Li F, Sullivan K, Greene DA, Larkin D, Stevens MJ.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Michigan Diabetes Research and Training Center, University of Michigan, Ann Arbor Veterans Administration Hospitals, 48109-0678, USA.


Autonomic neuropathy in streptozotocin diabetic rats: effect of acetyl-L-carnitine.

Lo Giudice P, Careddu A, Magni G, Quagliata T, Pacifici L, Carminati P.

Department of Pharmacology, Research and Development, Sigma Tau, Pomezia 00040, Italy. guidicepietro.lo@sigma-tau.it


L-carnitine and acetyl-L-carnitine in human nerves from normal and diabetic subjects.

Scarpini E, Doneda P, Pizzul S, Chiodi P, Ramacci MT, Baron P, Conti G, Sacilotto G, Arduini A, Scarlato G.

Department of Neurology, Dino Ferrari Center, IRCCS Ospedale Maggiore, Milano, Italy.


Effects of ALCAR on the fast axoplasmic transport in cultured sensory neurons of streptozotocin-induced diabetic rats.

Kano M, Kawakami T, Hori H, Hashimoto Y, Tao Y, Ishikawa Y, Takenaka T.

Department of Physiology, Yokohama City University School of Medicine, Japan.


Polyol pathway hyperactivity is closely related to carnitine deficiency in the pathogenesis of diabetic neuropathy of streptozotocin-diabetic rats.

Nakamura J, Koh N, Sakakibara F, Hamada Y, Hara T, Sasaki H, Chaya S, Komori T, Nakashima E, Naruse K, Kato K, Takeuchi N, Kasuya Y, Hotta N.

The Third Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan.


Multicenter study of the incidence of and predictive risk factors for diabetic neuropathic foot ulceration.

Abbott CA, Vileikyte L, Williamson S, Carrington AL, Boulton AJ.

Department of Medicine, Manchester Royal Infirmary, U.K. caroline@footclinic.demon.co.uk


Metabolic and vascular factors in the pathogenesis of diabetic neuropathy.

Cameron NE, Cotter MA.

Department of Biomedical Sciences, University of Aberdeen, Scotland, U.K.


Acetyl-L-carnitine effects on nerve conduction and glycemic regulation in experimental diabetes.

Soneru IL, Khan T, Orfalian Z, Abraira C.

Extended Care & Geriatrics Service (181C), Hines VA Hospital, Illinois 60141, USA.


L-carnitine treatment improves brain stem auditory evoked potentials in diabetic rats.

Yildiz O, Ozata M, Ozkardes A, Corakci A, Gundogan N, Gundogan MA.

Department of Pharmacology, Gulhane School of Medicine, Ankara, Turkey.


Comparison of the effects of aminoguanidine and L-carnitine treatments on somatosensorial evoked potentials in alloxan-diabetic rats.

Yildiz O, Ozata M, Ozkardes A, Deniz G, Yildirimkaya M, Corakci A, Yardim M, Gundogan MA.

Department of Medical Pharmacology, Gulhane School of Medicine, Ankara, Turkey.


The effects of acetyl-L-carnitine and sorbinil on peripheral nerve structure, chemistry, and function in experimental diabetes.

Malone JI, Lowitt S, Salem AF, Miranda C, Korthals JK, Carver J.

Diabetes Center and the Department of Pediatrics, University of South Florida, Tampa, FL 33612-4799, USA.


Acetyl-L-carnitine deficiency as a cause of altered nerve myo-inositol content, Na,K-ATPase activity, and motor conduction velocity in the streptozotocin-diabetic rat.

Stevens MJ, Lattimer SA, Feldman EL, Helton ED, Millington DS, Sima AA, Greene DA.

Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.

N-Acetyl-Cysteine

Methylglyoxal induces apoptosis through oxidative stress-mediated activation of p38 mitogen-activated protein kinase in rat Schwann cells.

Fukunaga M, Miyata S, Higo S, Hamada Y, Ueyama S, Kasuga M.

Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.


Effects of the sulphydryl donor N-acetyl-L-cysteine on nerve conduction, perfusion, maturation and regeneration following freeze damage in diabetic rats.

Love A, Cotter MA, Cameron NE.

Department of Biomedical Sciences, University of Aberdeen, UK.


Inhibition of development of peripheral neuropathy in streptozotocin-induced diabetic rats with N-acetylcysteine.

Sagara M, Satoh J, Wada R, Yagihashi S, Takahashi K, Fukuzawa M, Muto G, Muto Y, Toyota T.

Third Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.

Selenium

Oxidants downstream from superoxide inhibit nitric oxide production by vascular endothelium--a key role for selenium-dependent enzymes in vascular health.

McCarty MF.

Nutrition 21, San Diego, CA 92109, USA.


[Diabetes mellitus--a free radical-associated disease. Results of adjuvant antioxidant supplementation]

[Article in German]

Kahler W, Kuklinski B, Ruhlmann C, Plotz C.

Klinik fur Innere Medizin, Klinikums Rostock-Sudstadt.

Lipoic Acid

Diabetic neuropathy.

Bansal V, Kalita J, Misra UK.

Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareilly Road, Lucknow 226014, India.


[Lipoic acid: characteristics and therapeutic application]

[Article in Polish]

Malinska D, Winiarska K.

Zaklad Regulacji Metabolizmu, Instytut Biochemii, Uniwersytet Warszawski.


[Predictors of alpha-lipoic acid treatment efficacy in diabetic polyneuropathy of the lower limbs]

[Article in Russian]

Bregovskii VB, Posokhina OV, Karpova IA.


Induction of heat shock proteins may combat insulin resistance.

McCarty MF.

Natural Alternatives International, 1185 Linda Vista Dr., San Marcos, CA 92078, United States.


Endogenous production of lipoic acid is essential for mouse development.

Yi X, Maeda N.

Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill, 701 Brinkhous-Bullitt Building, Chapel Hill, NC 27599-7525, USA.


Thioctic acid for patients with symptomatic diabetic polyneuropathy: a critical review.

Ziegler D.

German Diabetes Clinic, German Diabetes Research Institute, Leibniz Institute at the Heinrich Heine University, Dusseldorf, Germany. dan.ziegler@ddfi.uni-duesseldorf.de


Utilization of the insulin-signaling network in the metabolic actions of alpha-lipoic acid-reduction or oxidation?

Konrad D.

Division of Endocrinology and Diabetology, University Children's Hospital, Zurich, Switzerland. daniel.konrad@kispi.unizh.ch


[Regional anesthesia and timely treatment for neuropathy in patients with pyonecrotic forms of the diabetic foot]

[Article in Russian]

Orudzheva SA, Zviagin AA, Simonenkov AP, Tsvetkov VO, Kurochkina AI, Klenskii SK, Braverman IB.


Treatment for diabetic mononeuropathy with alpha-lipoic acid.

Tankova T, Cherninkova S, Koev D.

Clinic of Diabetology,Clinical Centre of Endocrinology, Clinic of Neurology, Medical University, Sofia, Bulgaria. tankova@iname.com


Short-term hyperglycemia produces oxidative damage and apoptosis in neurons.

Vincent AM, McLean LL, Backus C, Feldman EL.

University of Michigan, Department of Neurology, Ann Arbor, Michigan 48109, USA. andreav@umich.edu


[Evidence-based pharmacotherapy of neuropathic pain syndromes]

[Article in German]

Braune S.

Neurozentrum Prien. braune@neurozentrum-prien.de


Effects of 3-month treatment with the antioxidant alpha-lipoic acid in diabetic peripheral neuropathy.

Negrisanu G, Rosu M, Bolte B, Lefter D, Dabelea D.

Department of Diabetes, University of Medicine, Timisoara.


Diabetic neuropathy--choices of treatment.

Bruckner I, Bustan C, Adamescu E, Dobjanschi C.

"N. Malaxa" Hospital, Clinic of Diabetes, Nutrition and Metabolic Disease, 12, Sos.Vergului, Bucharest, Romania.


Neuroprotection by alpha-lipoic acid in streptozotocin-induced diabetes.

Baydas G, Donder E, Kiliboz M, Sonkaya E, Tuzcu M, Yasar A, Nedzvetskii VS.

Department of Physiology, Faculty of Medicine, Firat University, Elazig, 23119, Turkey. baydas@hotmail.com


Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress.

Smith AR, Shenvi SV, Widlansky M, Suh JH, Hagen TM.

Dept. of Biochemistry and Biophysics and the Linus Pauling Institute, 571 Weniger Hall, Oregon State University, Corvallis, Oregon 97331, USA.


Clinical experience with thioctacid (thioctic acid) in the treatment of distal symmetric polyneuropathy in Korean diabetic patients.

Hahm JR, Kim BJ, Kim KW.

Department of Internal Medicine, College of Medicine, Gyeongsang Institute of Health Science, Gyeongsang National University, Jinju, South Korea.


Prevention and partial reversal of diabetes-induced changes in enteric nerves of the rat ileum by combined treatment with alpha-lipoic acid and evening primrose oil.

Shotton HR, Broadbent S, Lincoln J.

Department of Anatomy and Developmental Biology, Autonomic Neuroscience Institute, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK.


Postmarketing surveillance of adverse drug reactions: a correlational study approach using multiple data sources.

Rathmann W, Haastert B, Delling B, Gries FA, Giani G.

Diabetes Research Institute at the Heinrich Heine University, Duesseldorf, Germany. rath@dfi.uni-duesseldorf.de


Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a meta-analysis.

Ziegler D, Nowak H, Kempler P, Vargha P, Low PA.

German Diabetes Research Institute, Leibriz Institute at the Heinrich Heine University, Dusseldorf, Germany. dan.ziegler@ddfi.uni-duesseldorf.de


Effects of alpha-lipoic acid on impaired gastric fundus innervation in diabetic rats.

Gibson TM, Cotter MA, Cameron NE.

Department of Biomedical Sciences, University of Aberdeen, Aberdeen, Scotland, United Kingdom.


Acute glucose deprivation leads to apoptosis in a cell model of acute diabetic neuropathy.

Honma H, Podratz JL, Windebank AJ.

Molecular Neuroscience PhD Program, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.


Preventing superoxide formation in epineurial arterioles of the sciatic nerve from diabetic rats restores endothelium-dependent vasodilation.

Coppey LJ, Gellett JS, Davidson EP, Yorek MA.

Veteran Affairs Medical Center, Diabetes Endocrinology Research Center and Department of Internal Medicine, University of Iowa, Iowa City, IA 52246, USA.


The sensory symptoms of diabetic polyneuropathy are improved with alpha-lipoic acid: the SYDNEY trial.

Ametov AS, Barinov A, Dyck PJ, Hermann R, Kozlova N, Litchy WJ, Low PA, Nehrdich D, Novosadova M, O'Brien PC, Reljanovic M, Samigullin R, Schuette K, Strokov I, Tritschler HJ, Wessel K, Yakhno N, Ziegler D; SYDNEY Trial Study Group.

Russian Medical Academy for Advanced Studies, Moscow, Russia.


Botanicals and dietary supplements in diabetic peripheral neuropathy.

Halat KM, Dennehy CE.

California College of Podiatric Medicine, San Francisco, Calif, USA.


The effectiveness of treatments of diabetic autonomic neuropathy is not the same in autonomic nerves supplying different organs.

Shotton HR, Clarke S, Lincoln J.

Department of Anatomy and Developmental Biology, Autonomic Neuroscience Institute, Royal Free and University College Medical School, London, U.K.


[Biologic properties of lipoic acid]

[Article in Polish]

Bilska A, Wlodek L.

Instytut Biochemii Lekarskiej Collegium Medicum Uniwersytetu Jagiellonskiego, Krakowie. mbbilska@cyf-kr.edu.pl


High-performance liquid chromatographic assay for alpha-lipoic acid and five of its metabolites in human plasma and urine.

Teichert J, Preiss R.

Department of Clinical Pharmacology, Faculty of Medicine, University of Leipzig, Germany. teij@medizin.uni-leipzig.de


Molecular aspects of lipoic acid in the prevention of diabetes complications.

Packer L, Kraemer K, Rimbach G.

Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90098-9121, USA. packerresearch@aol.com


Alpha-lipoic acid: a multifunctional antioxidant that improves insulin sensitivity in patients with type 2 diabetes.

Evans JL, Goldfine ID.

Medical Research Institute, San Bruno, California 94066, USA. jevans@lipoic.com


Glutathione and alpha-lipoate in diabetic rats: nerve function, blood flow and oxidative state.

van Dam PS, van Asbeck BS, Van Oirschot JF, Biessels GJ, Hamers FP, Marx JJ.

University Medical Center, Utrecht, The Netherlands. P.S.vanDam@digd.azu.nl


Oxidative stress participates in the breakdown of neuronal phenotype in experimental diabetic neuropathy.

Hounsom L, Corder R, Patel J, Tomlinson DR.

William Harvey Research Institute, Medical College, Charterhouse Square, London, UK.


The function of endogenous protective systems in patients with insulin-dependent diabetes mellitus and polyneuropathy: effect of antioxidant therapy.

Strokov IA, Manukhina EB, Bakhtina LY, Malyshev IY, Zoloev GK, Kazikhanova SI, Ametov AS.

Department of Endocrinology and Diabetology, Russian Medical Academy of Postgraduate Education, Moscow.


Lipoic acid decreases lipid peroxidation and protein glycosylation and increases (Na(+) + K(+))- and Ca(++)-ATPase activities in high glucose-treated human erythrocytes.

Jain SK, Lim G.

Department of Pediatrics, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA. sjain@lsuhsc.edu


Alternative therapies: Part I. Depression, diabetes, obesity.

Morelli V, Zoorob RJ.

Louisiana State University School of Medicine in New Orleans, USA.


Diabetic neuropathies.

Vinik AI, Park TS, Stansberry KB, Pittenger GL.

The Strelitz Diabetes Institutes, Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, Virginia 23510, USA.


Effects of alpha-lipoic acid on microcirculation in patients with peripheral diabetic neuropathy.

Haak E, Usadel KH, Kusterer K, Amini P, Frommeyer R, Tritschler HJ, Haak T.

Medical Department I, Center of Internal Medicine, University Hospital, Frankfurt, Germany. E.Haak@em.uni-frankfurt.de


Effects of DL-alpha-lipoic acid on peripheral nerve conduction, blood flow, energy metabolism, and oxidative stress in experimental diabetic neuropathy.

Stevens MJ, Obrosova I, Cao X, Van Huysen C, Greene DA.

Division of Endocrinology and Metabolism, University of Michigan, Ann Arbor 48109-0678, USA. stevensm@umich.edu


In vivo effect of lipoic acid on lipid peroxidation in patients with diabetic neuropathy.

Androne L, Gavan NA, Veresiu IA, Orasan R.

Diabetes Center & Clinic, Cluj Napoca.


Oxidants downstream from superoxide inhibit nitric oxide production by vascular endothelium--a key role for selenium-dependent enzymes in vascular health.

McCarty MF.

Nutrition 21, San Diego, CA 92109, USA.


Alpha-lipoic acid in the treatment of diabetic polyneuropathy in Germany: current evidence from clinical trials.

Ziegler D, Reljanovic M, Mehnert H, Gries FA.

Diabetes-Forschungsinstitut an der Heinrich-Heine-Universitat, Dusseldorf, Germany. dan.ziegler@dfi.uni-duesseldorf.de


Alpha-lipoic acid: effect on glucose uptake, sorbitol pathway, and energy metabolism in experimental diabetic neuropathy.

Kishi Y, Schmelzer JD, Yao JK, Zollman PJ, Nickander KK, Tritschler HJ, Low PA.

Department of Neurology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA.


Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy.

Reljanovic M, Reichel G, Rett K, Lobisch M, Schuette K, Moller W, Tritschler HJ, Mehnert H.

University of Clinic for Diabetes, Endocrinology and Metabolic Diseases Vuk Vrhovac, Medical faculty, University of Zagreb, Coratia.


Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a 7-month multicenter randomized controlled trial (ALADIN III Study). ALADIN III Study Group. Alpha-Lipoic Acid in Diabetic Neuropathy.

Ziegler D, Hanefeld M, Ruhnau KJ, Hasche H, Lobisch M, Schutte K, Kerum G, Malessa R.

Diabetes-Forschungsinstitut an der Heinrich-Heine-Universitat, Dusseldorf, Germany. dan.ziegler@dfi.uni-duesseldorf.de


[The efficacy of the intravenous administration of the trometamol salt of thioctic (alpha-lipoic) acid in diabetic neuropathy]

[Article in Russian]

Strokov IA, Kozlova NA, Mozolevskii IuV, Miasoedov SP, Iakhno NN.


[Drug prescriptions and costs in diabetic polyneuropathy]

[Article in German]

Rathmann W, Haastert B, Giani G.

Abteilung Biometrie und Epidemiologie, Diabetes Forschungsinstitut an der Heinrich Heine Universitat Dusseldorf. rath@dfi.uni-duesseldorf.de


The effect of alpha-lipoic acid on the neurovascular reflex arc in patients with diabetic neuropathy assessed by capillary microscopy.

Haak ES, Usadel KH, Kohleisen M, Yilmaz A, Kusterer K, Haak T.

Center of Internal Medicine, Johann Wolfgang Goethe-University, Frankfurt, D-60590, Germany.


Effects of diabetes and treatment with the antioxidant alpha-lipoic acid on endothelial and neurogenic responses of corpus cavernosum in rats.

Keegan A, Cotter MA, Cameron NE.

Department of Biomedical Sciences, University of Aberdeen, Scotland, UK.


Dose-proportionality of oral thioctic acid--coincidence of assessments via pooled plasma and individual data.

Breithaupt-Grogler K, Niebch G, Schneider E, Erb K, Hermann R, Blume HH, Schug BS, Belz GG.

Center for Cardiovascular Pharmacology, Mathildenstrasse 8, 55116, Mainz, Germany.

 


Metabolic effects of thioctic acid in rodent models of insulin resistance and diabetes.

Black K, Qu X, Seale JP, Donnelly R.

Department of Pharmacology, University of Sydney, New South Wales, Australia.


Insufficient glycemic control increases nuclear factor-kappa B binding activity in peripheral blood mononuclear cells isolated from patients with type 1 diabetes.

Hofmann MA, Schiekofer S, Kanitz M, Klevesath MS, Joswig M, Lee V, Morcos M, Tritschler H, Ziegler R, Wahl P, Bierhaus A, Nawroth PP.

Department of Medicine, University of Heidelberg, Germany.


A lipoic acid-gamma linolenic acid conjugate is effective against multiple indices of experimental diabetic neuropathy.

Hounsom L, Horrobin DF, Tritschler H, Corder R, Tomlinson DR.

Department of Pharmacology, Queen Mary and Westfield College, London, UK.


Effects of alpha-lipoic acid on neurovascular function in diabetic rats: interaction with essential fatty acids.

Cameron NE, Cotter MA, Horrobin DH, Tritschler HJ.

Department of Biomedical Sciences, University of Aberdeen, Scotland, UK.


Alpha-lipoic acid in the treatment of diabetic peripheral and cardiac autonomic neuropathy.

Ziegler D, Gries FA.

Diabetes Research Institute at the Heinrich Heine University, Dusseldorf, Germany.


Lipoic acid reduces the activities of biotin-dependent carboxylases in rat liver.

Zempleni J, Trusty TA, Mock DM.

Department of Pediatrics, University of Arkansas for Medical Sciences and the Arkansas Children's Hospital Research Institute, Little Rock, AR 72202, USA.


Effects of treatment with the antioxidant alpha-lipoic acid on cardiac autonomic neuropathy in NIDDM patients. A 4-month randomized controlled multicenter trial (DEKAN Study). Deutsche Kardiale Autonome Neuropathie.

Ziegler D, Schatz H, Conrad F, Gries FA, Ulrich H, Reichel G.

Diabetes-Forschungsinstitut an der Heinrich-Heine-Universitat, Dusseldorf, Germany.


Neuroprotection by the metabolic antioxidant alpha-lipoic acid.

Packer L, Tritschler HJ, Wessel K.

Department of Molecular and Cell Biology, University of California, Berkeley 94720-3200, USA.


Stimulation of glucose uptake by the natural coenzyme alpha-lipoic acid/thioctic acid: participation of elements of the insulin signaling pathway.

Estrada DE, Ewart HS, Tsakiridis T, Volchuk A, Ramlal T, Tritschler H, Klip A.

Division of Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada.


Alpha-lipoic acid: antioxidant potency against lipid peroxidation of neural tissues in vitro and implications for diabetic neuropathy.

Nickander KK, McPhee BR, Low PA, Tritschler H.

Department of Neurology, Mayo Foundation, Rochester, MN 55905, USA.


Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant alpha-lipoic acid. A 3-week multicentre randomized controlled trial (ALADIN Study).

Ziegler D, Hanefeld M, Ruhnau KJ, Meissner HP, Lobisch M, Schutte K, Gries FA.

Diabetes-Forschungsinstitut an der Heinrich-Heine-Universitat, Dusseldorf, Germany.


Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy.

Nagamatsu M, Nickander KK, Schmelzer JD, Raya A, Wittrock DA, Tritschler H, Low PA.

Department of Neurology, Mayo Foundation, Rochester, Minnesota 55905, USA.


Thioctic (lipoic) acid: a therapeutic metal-chelating antioxidant?

Ou P, Tritschler HJ, Wolff SP.

Department of Medicine, University College London Medical School, U.K.


[Diabetes mellitus--a free radical-associated disease. Results of adjuvant antioxidant supplementation]

[Article in German]

Kahler W, Kuklinski B, Ruhlmann C, Plotz C.

Klinik fur Innere Medizin, Klinikums Rostock-Sudstadt.


[Diabetic autonomic neuropathy of the heart and its treatment with thioctic acid]

[Article in German]

Studt J, Heuer LJ.


Efficacy of thioctic acid in the therapy of peripheral diabetic neuropathy.

Sachse G, Willms B.


[Treatment of diabetic neuropathy with oral alpha-lipoic acid (author's transl)]

[Article in German]

Klein W.



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* NeuropathyRx® for treatment of peripheral neuropathy, diabetic neuropathy, neurofibromatosis, fibromyalgia, and multiple sclerosis. We specialize in neuropathy, neurofibromatosis, nerve, and neurological treatment through the use of natural vitamin supplements specifically formulated for the treatment of neuropathy and neurofibromatosis. Information contained on this site is not intended to diagnose, prescribe for, treat, or claim to prevent, mitigate or cure any disease. While literature suggests that the supplements made available on this site may be very helpful in the treatment of neuropathy, neurofibromatosis, fibromyalgia, multiple sclerosis and other neurological conditions, they have not been approved by the Food and Drug Administration and individual results may vary. Consumers are cautioned to read all labels and follow all directions. Please consult with your health care provider before using these products to treat your neuropathy, neurofibromatosis, fibromyalgia, or multiple sclerosis. The information on this website should not in any way be used as a substitute for the advice of a physician or other licensed health care practitioner. We shall not be held liable or responsible to any person or entity for any loss or damage caused, or alleged to be have been caused, directly or indirectly by the information or ideas contained, suggested, or referenced on this web site. Please take a moment to read our studies on neuropathy and neurofibromatosis and learn how we discovered NeuropathyRx® for treatment of neuropathy pain, neuropathy burning, neuropathy numbness, and all forms of peripheral neuropathy including diabetic neuropathy and neuropathy induced by chemotherapy in addition to neurofibromatosis.
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